Reserpine treatment activates AMP activated protein kinase (AMPK)
نویسندگان
چکیده
منابع مشابه
Phenformin activates the unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner.
BACKGROUND The cross-talk between UPR activation and metabolic stress remains largely unclear. RESULTS Phenformin treatment activates the IRE1α and PERK pathways in an AMPK-dependent manner. CONCLUSION AMPK is required for phenformin-mediated IRE1α and PERK activation. SIGNIFICANCE Our findings demonstrate the cross-talk between UPR and metabolic signals. Activation of the unfolded protei...
متن کاملPhenformin Activates Unfolded Protein Response in an AMP-Activated Protein Kinase (AMPK)-Dependent Manner
Activation of unfolded protein response (UPR) is associated with the disruption of endoplasmic reticulum (ER) homeostasis and has been implicated in the pathogenesis of many human metabolic diseases, including obesity and type-2 diabetes. However, the nature of the signals activating UPR under these conditions remains largely unknown. Using a method that we recently optimized to directly measur...
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Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric complex that senses intracellular energy status and exerts rapid regulation on energy-demanding and -consuming metabolic pathways. Although alterations in the intracellular adenosine nucleotide pool are traditionally assumed to be the consequence of changes in energy metabolism, in this study we have addressed the...
متن کاملCordycepin activates AMP-activated protein kinase (AMPK) via interaction with the γ1 subunit
Cordycepin is a bioactive component of the fungus Cordyceps militaris. Previously, we showed that cordycepin can alleviate hyperlipidemia through enhancing the phosphorylation of AMP-activated protein kinase (AMPK), but the mechanism of this stimulation is unknown. Here, we investigated the potential mechanisms of cordycepin-induced AMPK activation in HepG2 cells. Treatment with cordycepin larg...
متن کاملIsoquercitrin activates the AMP–activated protein kinase (AMPK) signal pathway in rat H4IIE cells
BACKGROUND Isoquercitrin, a flavonoid compound that is widely distributed in medicinal and dietary plants, possesses many biological activities, including inhibition of adipocyte differentiation. In this study, we investigated the effect of isoquercitrin on lipid accumulation and its molecular mechanisms in rat hepatoma H4IIE cells. METHODS To investigate the effect of isoquercitrin on lipid ...
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ژورنال
عنوان ژورنال: Natural Product Sciences
سال: 2017
ISSN: 1226-3907,2288-9027
DOI: 10.20307/nps.2017.23.3.157